2026Journal articleFree to read

The possible Protective Effect of Matcha green tea against Acetic acid-induced colonic injury in Adult Albino Rats

Federal Institute for Risk Assessment

Bundesinstitut für Risikobewertung Fachgruppe ZEBET - Datenbank und Informationsbeschaffung Abteilung Experimentelle Toxikologie und ZEBET

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Abstract

The present experimental study aims to investigate the possible protective effect of Matcha green tea against acetic acid-induced colonic injury in adult male albino rats using histological, morphometric, and immunohistochemical methods.The study will be conducted at the Animal House, Faculty of Medicine, Sohag University. Thirty healthy adult male albino rats weighing 180–220 g will be used. The animals will be housed under standard laboratory conditions with free access to standard diet and water and will be acclimatized for one week before the experiment.The rats will be randomly divided into three equal groups, with 10 rats in each group. Group I will serve as the control group and will receive distilled water orally by gastric gavage once daily throughout the experimental period. Group II will receive a single intrarectal administration of 2 mL of 4% acetic acid solution (v/v in 0.9% saline) through a soft pediatric catheter measuring 2.7 mm in diameter. After administration, the animals will be maintained in a vertical position for approximately 2 minutes to prevent leakage. Group III will receive Matcha green tea orally by gastric gavage at a dose of 200 mg/kg body weight/day for 7 consecutive days. On day 8, the last Matcha dose will be followed by a single intrarectal administration of 2 mL of 4% acetic acid to induce colonic injury.All animals will be sacrificed 48 hours after acetic acid administration. Colon specimens will be removed, rinsed with normal saline, fixed in 10% neutral buffered formalin, processed for paraffin embedding, and sectioned at 5 µm thickness. The tissue sections will be stained with hematoxylin and eosin (H&E) and Alcian blue and examined using a light microscope. Immunohistochemical staining using an antibody against myeloperoxidase…

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Study type

Animal study

Experiments in mice, rats, fish or other animals.

Assigned automatically from the title, abstract and subject terms.

Topics

Gut and microbiome Inflammation and immunity Metabolism and weight Skin, oral and dental

Matcha is a main subject here (named in the title).

Keywords and subject terms

myeloperoxidase neutrophil infiltration anti-inflammatory activity colitis colon histopathology Alcian blue staining

Cite this study

Federal Institute for Risk Assessment. (2026). The possible Protective Effect of Matcha green tea against Acetic acid-induced colonic injury in Adult Albino Rats. Bundesinstitut für Risikobewertung Fachgruppe ZEBET - Datenbank und Informationsbeschaffung Abteilung Experimentelle Toxikologie und ZEBET. https://doi.org/10.17590/asr.0000459

DOI: 10.17590/asr.0000459

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