2024Journal articleFree to read
Luo Y, Wen Y, Huang J, Chen B, Lv S, Qiu H, Li S, Liu S, Yang Q, He L, Yu Z, Zhao M, and 3 more
Current research in food science
Matcha shows promise for diabetes, obesity, and gut microbiota disorders. Studies suggest a significant link between gut microbiota, metabolites, and obesity. Thus, matcha may have a positive impact on obesity by modulating gut microbiota and metabolites. This study used 16S rDNA sequencing and untargeted metabolomics to examine the cecal contents in mice. By correlation analysis, we explored the potential mechanisms responsible for the positive effects of matcha on obesity. The results indicated that matcha had a mitigating effect on the detrimental impacts of a high-fat diet (HFD) on multiple physiological indicators in mice, including body weight, adipose tissue weight, serum total cholesterol (TC), and low-density lipoprotein (LDL) levels, as well as glucose tolerance. Moreover, it was observed that matcha had an impact on the structural composition of gut microbiota and gut metabolites. Specifically, matcha was able to reverse the alterations in the abundance of certain obesity-improving bacteria, such as Alloprevotella, Ileibacterium, and Rikenella, as well as the abundance of obesity-promoting bacteria Romboutsia, induced by a HFD. Furthermore, matcha can influence the levels of metabolites, including formononetin, glutamic acid, pyroglutamic acid, and taurochenodeoxycholate, within the gastrointestinal tract. Additionally, matcha enhances caffeine metabolism and the HIF-1 signaling pathway in the KEGG pathway. The results of the correlation analysis suggest that formononetin, theobromine, 1,3,7-trimethyluric acid, and Vitamin C displayed negative correlation with both the obesity phenotype and microbiota known to exacerbate obesity, while demonstrating positive correlations with microbiota that alleviated obesity. However, glutamic acid, pyroglutamic acid, and…
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Study type
Animal study
Experiments in mice, rats, fish or other animals.
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Topics
Matcha is a main subject here (named in the title).
Luo Y, Wen Y, Huang J, Chen B, Lv S, Qiu H, … Gu C. (2024). Matcha alleviates obesity by modulating gut microbiota and its metabolites. Current research in food science. https://doi.org/10.1016/j.crfs.2024.100823
DOI: 10.1016/j.crfs.2024.100823 · PubMed ID: 39253721 · Cited by 18 (OpenAlex)
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