2019Journal articleFree to read

Evaluation of ethanol-based extraction conditions of sorghum bran bioactive compounds with downstream anti-proliferative properties in human cancer cells.

Cox S, Noronha L, Herald T, Bean S, Lee SH, Perumal R, Wang W, Smolensky D

Heliyon

Read at the publisher →PubMed PubMed Central

Abstract

Certain foods such as turmeric and green tea have been extensively studied for anticancer properties, while high polyphenol sorghum has not received the same attention. Some bioactive compounds in Sorghum bicolor with anticancer activity have been identified, indicating the further need for research and screening methods of high polyphenol sorghum varieties. This study was aimed at improving the extraction of sorghum bioactive compounds by using food-grade solvents using ethanol and citric acid. We used three sorghum varieties and green tea (GT) as a control. The extraction methods were screened for anti-proliferative properties in HepG2 and HCT-15 cancer cell lines, using a cell viability assay. Extraction conditions were improved for anti-proliferative compounds from a high-phenolic sorghum variety (HP), sumac sorghum (CS), and GT. HP was more effective at inhibiting cell viability than CB, CS, and GT. The results demonstrate an efficient method for extracting sorghum bioactive compounds for future anticancer research using food approved ingredients.

Abstract text comes from PubMed, OpenAlex or Europe PMC and belongs to the authors and publisher.

Study type

In vitro / cell study

Lab experiments on cells or isolated systems.

Assigned automatically from the title, abstract and subject terms.

Topics

Cancer Processing, milling and quality Cognition, mood and stress Antioxidants and polyphenols

Matcha is a main subject here (named in the keywords).

Keywords and subject terms

CB, Commercial black sorghum bran CS, Commercial sumac sorghum bran Cell biology Food science GT, Matcha green tea powder HP, High phenolic black sorghum bran PI570481 Natural product chemistry Cb, Commercial Black Sorghum Bran Cs, Commercial Sumac Sorghum Bran Gt, Matcha Green Tea Powder Hp, High Phenolic Black Sorghum Bran Pi570481

Cite this study

Cox S, Noronha L, Herald T, Bean S, Lee SH, Perumal R, … Smolensky D. (2019). Evaluation of ethanol-based extraction conditions of sorghum bran bioactive compounds with downstream anti-proliferative properties in human cancer cells. Heliyon. https://doi.org/10.1016/j.heliyon.2019.e01589

DOI: 10.1016/j.heliyon.2019.e01589 · PubMed ID: 31111105 · Cited by 21 (OpenAlex)

More on cancer

2019Journal articleFree to read

Effects of green tea, matcha tea and their components epigallocatechin gallate and quercetin on MCF‑7 and MDA-MB-231 breast carcinoma cells.

Schröder L, Marahrens P, Koch JG, et al. — Oncology reports

We investigated the anticarcinogenic potential of green tea and its components epigallocatechin gallate (EGCG) and quercetin, as well as tamoxifen, on MCF-7 and MDA-MB-23 breast cancer cells. Using high-performance liquid chromatography,…

In vitro / cell studyAntioxidants and polyphenolsCancerInflammation and immunityCited 76×

2018Journal articleFree to read

Matcha green tea (MGT) inhibits the propagation of cancer stem cells (CSCs), by targeting mitochondrial metabolism, glycolysis and multiple cell signalling pathways.

Bonuccelli G, Sotgia F, Lisanti MP — Aging

Matcha green tea (MGT) is a natural product that is currently used as a dietary supplement and may have significant anti-cancer properties. However, the molecular mechanism(s) underpinning its potential health benefits remain largely…

In vitro / cell studyMetabolism and weightAntioxidants and polyphenolsCancerCited 66×

1985Journal article

Case-control study of urinary bladder cancer in metropolitan Nagoya.

Ohno Y, Aoki K, Obata K, et al. — National Cancer Institute monograph

We conducted a population-based case-control study of patients with bladder cancer and of controls drawn randomly from the general population of Metropolitan Nagoya and interviewed both groups. The incidence rates of bladder cancer were…

Randomized controlled trialCancerSkin, oral and dentalMarket, culture and sustainabilityCited 64×

1999Journal article

Inhibition of urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine in rats by green tea.

Sato D — International journal of urology : official journal of the Japanese Urological Association

Background: Recently, the anticarcinogenic effects of green tea have been studied in sites other than the urinary tract. The present study examined the inhibition by green tea of vesical tumors induced in rats by N-butyl-N-(4-hydroxybutyl)…

Animal studyAntioxidants and polyphenolsCancerMetabolism and weightCited 44×

Browse the whole library →